The second season of the National Heads-Up Poker Championship was filmed in 2006 at Caesars Palace in Las Vegas, Nevada. Some of poker's brightest stars, including defending champion Phil Hellmuth alongside Daniel Negreanu, Antonio Esfandiari, Phil Ivey, Chris Moneymaker, Michael Mizrachi, Mike Sexton, Doyle Brunson, Erick Lindgren, Jerry Buss, Greg Raymer, David "Chip" Reese, and Erik Seidel, all competed to win the $500,000 first-place prize.